The Spaniard has racked up nine titles from 13 tournaments contested since coming back from injury, putting himself on course to wrestle the world number one spot away from his opponent.
Monday's final will be a 37th clash between the pair, eclipsing the ATP World Tour Open Era record previously held by the Ivan Lendl-John McEnroe rivalry.
Nadal currently leads the head-to-head 21-15 having won five of their last six meetings after suffering seven successive final defeats to the Serb.
However, all but one of those recent triumphs came on clay courts, while the Serb has won 11 of their 17 meetings on hard courts, with a four-match winning streak on the surface ended by his three-set loss in Montreal last month.
That victory in Canada prompted the bookmaker's to move Nadal to the head of the betting for the US Open, a position which has only strengthened during the fortnight of action in New York.
Sky Bet make the Spaniard 4/6 favourite as he heads into the clash on the back of a 21-match unbeaten streak on the surface in question, having landed Masters 1000 titles in Indian Wells, Cincinnati and Montreal.
The nature of Nadal's recent success is all the more remarkable, dropping a solitary set en route to the final and having his service broken just once.
Djokovic is not to be written off, however, having won four of the last six majors contested on hard courts, being denied in finals on the other two occasions.
Picking a winner from this renewal of one of sport's greatest rivalries looks an unenviable task, but with 18 sets being contested in their last four Grand Slam meetings another epic clash looks inevitable.